Article
Strong association between glucocerebrosidase mutations and Parkinson's disease in Sweden.
Neurobiology of aging - 1 Sept 2016
Ran Caroline, Brodin Lovisa, Forsgren Lars, Westerlund Marie, Ramezani Mehrafarin, Gellhaar Sandra, Xiang Fengqing, Fardell Camilla, Nissbrandt Hans, Söderkvist Peter, Puschmann Andreas, Ygland Emil, Olson Lars, Willows Thomas, Johansson Anders, Sydow Olof, Wirdefeldt Karin, Galter Dagmar, Svenningsson Per, Belin Andrea Carmine
Abstract excerpt
Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohort reported to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.