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Mutations in glucocerebrosidase are a major genetic risk factor for Parkinson's disease and increase susceptibility to dementia in a Flanders-Belgian cohort.

Neuroscience letters - 26 Aug 2016

Crosiers David, Verstraeten Aline, Wauters Eline, Engelborghs Sebastiaan, Peeters Karin, Mattheijssens Maria, De Deyn Peter P, Theuns Jessie, Van Broeckhoven Christine, Cras Patrick

Abstract excerpt

OBJECTIVE: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations. METHODS: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well-characterized PD patients and 536 healthy control individuals. RESULTS: We identified rare, heterozygous GBA mutations in 12 PD...

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PMID: 27397011
DOI: 10.1016/j.neulet.2016.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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