Article
The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism.
Movement disorders : official journal of the Movement Disorder Society - 15 Aug 2009
DePaolo John, Goker-Alpan Ozlem, Samaddar Ted, Lopez Grisel, Sidransky Ellen
Abstract excerpt
A body of work has emerged over the past decade demonstrating a relationship between mutations in glucocerebrosidase gene (GBA), the gene implicated in Gaucher disease (GD), and the development of parkinsonism. Several different lines of research support this relationship. First, patients with GD who are homozygous for mutations in GBA have a higher than expected propensity to develop Parkinson's disease (PD)....
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