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Article

The origin of the cooperativity in the streptavidin-biotin system: A computational investigation through molecular dynamics simulations.

Scientific reports - 1 Jun 2016

Liu Fengjiao, Zhang John Z H, Mei Ye

Abstract excerpt

Previous experimental study measuring the binding affinities of biotin to the wild type streptavidin (WT) and three mutants (S45A, D128A and S45A/D128A double mutant) has shown that the loss of binding affinity from the double mutation is larger than the direct sum of those from two single mutations. The origin of this cooperativity has been investigated in this work through molecular dynamics simulations and the...

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Identifiers

PMID: 27249234
DOI: 10.1038/srep27190
PMCID: PMC4888747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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