Article
Entropic effect and residue specific entropic contribution to the cooperativity in streptavidin-biotin binding.
Nanoscale - 7 Apr 2020
Cong Yalong, Huang Kaifang, Li Yuchen, Zhong Susu, Zhang John Z H, Duan Lili
Abstract excerpt
Molecular dynamics (MD) simulations were performed employing the polarized protein-specific charge (PPC) to explore the origin of the cooperativity in streptavidin-biotin systems (wild type, two single mutations and one double-mutation). The results of the experiment found that the existence of cooperativity is mainly the result of the entropic effect. In this study, the entropic contribution to the binding free...
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