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Article

In vivo modulation of endothelial polarization by Apelin receptor signalling

1 Jun 2016

Abstract excerpt

Endothelial cells (ECs) respond to shear stress by aligning in the direction of flow. However, how ECs respond to flow in complex in vivo environments is less clear. Here we describe an endothelial-specific transgenic zebrafish line, whereby the Golgi apparatus is labelled to allow for in vivo analysis of endothelial polarization. We find that most ECs polarize within 4.5 h after the onset of vigorous blood flow...

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PMID: 27248505
DOI: 10.1038/ncomms11805

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