Article
Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease.
Experimental neurology - 1 Dec 1998
Lidström A M, Bogdanovic N, Hesse C, Volkman I, Davidsson P, Blennow K
Abstract excerpt
We studied the multifunctional protein clusterin (apolipoprotein J, SGP-2, SP-40,40) in brain tissue using quantitative Western blotting and immunohistochemistry. The material included postmortem brains from 19 patients with Alzheimer's disease (AD), 6 with vascular dementia (VAD), and 7 age-matc...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Blotting, Western
- Cerebral Cortex
- Clusterin
- Complement Inactivator Proteins
- Female
- Frontal Lobe
- Gene Frequency
- Glycoproteins
- Hippocampus
- Humans
- Immunohistochemistry