Article

Augmenting MEK inhibitor Efficacy in BRAF Wild-Type Melanoma: Synergistic Effects of Disulfiram Combination Therapy

2023-08-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus, novel combinations are needed to increase the efficacy and duration of response to MEKi in BRAF WT melanoma. Disulfiram and its metabo...

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Literature Corpus work: 9f540602-d0c2-5c00-8750-361f338bccc0
DOI: 10.21203/rs.3.rs-3258362/v1

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