Article
Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes.
Zebrafish - 1 Dec 2008
Hultman Keith A, Scott Alexander W, Johnson Stephen L
Abstract excerpt
Zebrafish is gaining popularity as a vertebrate model for screening small molecules that affect specific phenotypes or genetic pathways. In this study, we present a targeted drug screen to identify drug modifiers of the melanocyte migration defect of a temperature-sensitive allele of the Kit receptor tyrosine kinase, kit(ts). We first test two candidate drugs, the phosphatidylinositol-3-kinase kinase inhibitor...
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