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[Mutations of FBXW7 in Adult T-Cell Acute Lymphocytic Leukemia].

Zhongguo shi yan xue ye xue za zhi - 1 Jun 2015

Guo Xing, Zhang Run, Ge Zheng, Xu Jing-Yan, Li Min, Qiao Chun, Qiu Hai-Rong, Li Jian-Yong

Abstract excerpt

BACKGROUD: F-Box and WD40 domain containing protein 7 gene (FBXW7) is part of the E3 ubiquitin ligase complex that controls the turnover of various proteins including NOTCH1, c-MYC and Cyclin E. OBJECTIVE: To investigate the mutations of FBXW7 gene in adult T-cell acute lymphoblastic leukemia (T-ALL). METHODS: Exon 5-12 of FBXW7 were amplified, cloned and sequenced in 54 adult T-ALL patients; the frequency,...

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Source

Identifiers

PMID: 26117003
DOI: 10.7534/j.issn.1009-2137.2015.03.002

Genes

NOTCH1
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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