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Article

Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection.

International journal of medical microbiology : IJMM - 1 Sept 2016

Pérez-Lago Laura, Rodríguez Borlado Ana Isabel, Comas Iñaki, Herranz Marta, Ruiz-Serrano María Jesús, Bouza Emilio, García-de-Viedma Darío

Abstract excerpt

Clonal variants of Mycobacterium tuberculosis (MTB) coexist in specific patients, although the dynamics of their emergence is unknown. We used MIRU-VNTR to detect microevolution leading to variants of MTB in 3 out of 19 patients (15%) soon after diagnosis (61-85days). Most harbored SNPs and for some of them a potential functional role was suggested. Microevolution in tuberculosis seems to occur sooner and more...

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Identifiers

PMID: 27247102
DOI: 10.1016/j.ijmm.2016.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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