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Article

Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient.

International journal of medical microbiology : IJMM - 1 Dec 2013

Navarro Yurena, Pérez-Lago Laura, Sislema Fernanda, Herranz Marta, de Juan Lucía, Bouza Emilio, García-de-Viedma Darío

Abstract excerpt

Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution phenomena. The functional significance of these subtle genetic rearrangements is normally disregarded. We show that clonal variants from two patients had different infective behaviours in some in vitro cellular infection models but not in others. Microevolution may have a subtle impact on infectivity, but specific experimental...

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Identifiers

PMID: 24183098
DOI: 10.1016/j.ijmm.2013.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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