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Article

Angioedema attacks in patients with hereditary angioedema: Local manifestations of a systemic activation process.

The Journal of allergy and clinical immunology - 1 Aug 2016

Hofman Zonne L M, Relan Anurag, Zeerleder Sacha, Drouet Christian, Zuraw Bruce, Hack C Erik

Abstract excerpt

Hereditary angioedema (HAE) caused by a deficiency of functional C1-inhibitor (C1INH) becomes clinically manifest as attacks of angioedema. C1INH is the main inhibitor of the contact system. Poor control of a local activation process of this system at the site of the attack is believed to lead to the formation of bradykinin (BK), which increases local vasopermeability and mediates angioedema on interaction with...

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Share to Angioedemas, Hereditary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27246526
DOI: 10.1016/j.jaci.2016.02.041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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