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Article

The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070.

Scientific reports - 1 Jun 2016

Shi Meng, Xia Jianhong, Xing Huaixin, Yang Wenjun, Xiong Xiangyu, Pan Wenting, Han Sichong, Shang Jinhua, Zhou Changchun, Zhou Liqing, Yang Ming

Abstract excerpt

Metallopeptidase 13 (MMP13), a well-known and highly regulated zinc-dependent MMP collagenase, plays a crucial part in development and progression of esophageal squamous cell carcinoma (ESCC). Therefore, we examined associations between ESCC susceptibility and four haplotype-tagging single nucleotide polymorphisms (htSNPs) using a two stage case-control strategy. Odds ratios (OR) and 95% confidence intervals (95%...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27245877
DOI: 10.1038/srep27013
PMCID: PMC4887914

Genes

MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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