Article
Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis.
JAMA neurology - 1 Jul 2016
Fogh Isabella, Lin Kuang, Tiloca Cinzia, Rooney James, Gellera Cinzia, Diekstra Frank P, Ratti Antonia, Shatunov Aleksey, van Es Michael A, Proitsi Petroula, Jones Ashley, Sproviero William, Chiò Adriano, McLaughlin Russell Lewis, Sorarù Gianni, Corrado Lucia, Stahl Daniel, Del Bo Roberto, Cereda Cristina, Castellotti Barbara, Glass Jonathan D, Newhouse Steven, Dobson Richard, Smith Bradley N, Topp Simon, van Rheenen Wouter, Meininger Vincent, Melki Judith, Morrison Karen E, Shaw Pamela J, Leigh P Nigel, Andersen Peter M, Comi Giacomo P, Ticozzi Nicola, Mazzini Letizia, D'Alfonso Sandra, Traynor Bryan J, Van Damme Philip, Robberecht Wim, Brown Robert H, Landers John E, Hardiman Orla, Lewis Cathryn M, van den Berg Leonard H, Shaw Christopher E, Veldink Jan H, Silani Vincenzo, Al-Chalabi Ammar, Powell John
Abstract excerpt
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset neurodegenerative disorder with a poor prognosis and a median survival of 3 years. However, a significant proportion of patients survive more than 10 years from symptom onset. OBJECTIVE: To identify gene variants influencing survival in ALS. DESIGN, SETTING, AND PARTICIPANTS: This genome-wide association study (GWAS) analyzed survival in...
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