Article
UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia.
Annals of neurology - 1 Jun 2025
Reus Lianne M, Willemse Sean W, de Boer Sterre C M, De Houwer Julie, Hartog Willem L, Mol Merel O, van Rooij Jeroen G J, Tesi Niccolo, Donker Kaat Laura, Hulsman Marc, Vijverberg Everard G B, Holstege Henne, van Rheenen Wouter, Veldink Jan H, van den Berg Leonard H, van Swieten John C, Seelaar H, van der Lee Sven J, van Es Michael A, Pijnenburg Yolande A L
Abstract excerpt
UNC13A (rs12608932-CC) is associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and shortens survival in ALS. We aim to describe the association for UNC13A and survival in FTD. We included 626 patients with FTD from Dutch memory clinics, including a subcohort of 150 patients with TDP-43 pathology. Survival analyses were performed using Cox proportional hazard models in a...
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