Article
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
Nature medicine - 1 Aug 2016
Nolan Emma, Vaillant François, Branstetter Daniel, Pal Bhupinder, Giner Göknur, Whitehead Lachlan, Lok Sheau W, Mann Gregory B, Rohrbach Kathy, Huang Li-Ya, Soriano Rosalia, Smyth Gordon K, Dougall William C, Visvader Jane E, Lindeman Geoffrey J
Abstract excerpt
Individuals who have mutations in the breast-cancer-susceptibility gene BRCA1 (hereafter referred to as BRCA1-mutation carriers) frequently undergo prophylactic mastectomy to minimize their risk of breast cancer. The identification of an effective prevention therapy therefore remains a 'holy grail' for the field. Precancerous BRCA1(mut/+) tissue harbors an aberrant population of luminal progenitor cells, and...
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