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Article

Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2004

Kapur Raj P, Yao Zhenqiang, Iida Malissa H K, Clarke Christine M, Doggett Barbara, Xing Lianping, Boyce Brendan F

Abstract excerpt

UNLABELLED: We report the first case of lethal autosomal recessive osteopetrosis in mice caused by a spontaneous 8-bp deletion in exon 2 of the Rank gene. The phenotype, including a block in RANKL-dependent osteoclast differentiation and lymph node agenesis, copies that of Rank(-/-) mice, which have been produced by targeted recombination. INTRODUCTION: Commitment of osteoclast progenitors to the osteoclast...

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Source

Identifiers

PMID: 15355564
DOI: 10.1359/JBMR.040713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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