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Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer.

Cancer letters - 28 Aug 2016

Kim Ji Young, Cho Youngkwan, Oh Eunhye, Lee Nahyun, An Hyunsook, Sung Daeil, Cho Tae-Min, Seo Jae Hong

Abstract excerpt

HER2-positive breast tumors are known to harbor cancer stem-like cell populations and are associated with an aggressive tumor phenotype and poor clinical outcomes. Disulfiram (DSF), an anti-alcoholism drug, is known to elicit cytotoxicity in many cancer cell types in the presence of copper (Cu). The objective of the present study was to investigate the mechanism of action responsible for the induction of...

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PMID: 27238567
DOI: 10.1016/j.canlet.2016.05.026

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