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Article

Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo.

Cancer research - 15 May 2010

Zhang Haijun, Chen Di, Ringler Jonathan, Chen Wei, Cui Qiuzhi Cindy, Ethier Stephen P, Dou Q Ping, Wu Guojun

Abstract excerpt

Frequent genetic alterations of the components in the phosphoinositide 3-kinase (PI3K)/PTEN/AKT signaling pathway contribute greatly to breast cancer initiation and progression, which makes targeting this signaling pathway a promising therapeutic strategy for breast cancer treatment. In this study, we showed that in the presence of copper (Cu), disulfiram (DSF), a clinically used antialcoholism drug, could...

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Identifiers

PMID: 20424113
DOI: 10.1158/0008-5472.CAN-09-3752
PMCID: PMC3827685

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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