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Article

Stressing over anxiety: A novel interaction of 5-HTTPLR genotype and anxiety-related phenotypes in older adults.

Psychoneuroendocrinology - 1 Sept 2016

Fogelman Nia, Mikhailik Anatoly, Mueller-Alcazar Anett, Bernard Kristin, Canli Turhan

Abstract excerpt

Variation within the serotonin transporter gene-linked polymorphic region (5-HTTPLR) contributes to individual differences in trait neuroticism and increases risk for the development of psychopathology in the context of stressful life events. The underlying mechanisms may involve dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of stress-related hormones. Yet, observed effects are...

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Identifiers

PMID: 27235638
DOI: 10.1016/j.psyneuen.2016.05.012
PMCID: PMC4955748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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