Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa.

doi:10.1111/evo.12958

Back to search

Article

Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa.

Evolution; international journal of organic evolution - 1 Jul 2016

Gifford Danna R, Toll-Riera Macarena, MacLean R Craig

Abstract excerpt

The idea that interactions between mutations influence adaptation by driving populations to low and high fitness peaks on adaptive landscapes is deeply ingrained in evolutionary theory. Here, we investigate the impact of epistasis on evolvability by challenging populations of two Pseudomonas aeru...

Topics

Biological Evolution
Carbon
Drug Resistance, Bacterial
Epistasis, Genetic
Fimbriae, Bacterial
Genotype
Mutation
Pseudomonas aeruginosa
Rifampin
Serine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.