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Article

Rab5 Isoforms Specifically Regulate Different Modes of Endocytosis in Leishmania.

The Journal of biological chemistry - 8 Jul 2016

Rastogi Ruchir, Verma Jitender Kumar, Kapoor Anjali, Langsley Gordon, Mukhopadhyay Amitabha

Abstract excerpt

Differential functions of Rab5 isoforms in endocytosis are not well characterized. Here, we cloned, expressed, and characterized Rab5a and Rab5b from Leishmania and found that both of them are localized in the early endosome. To understand the role of LdRab5 isoforms in different modes of endocytosis in Leishmania, we generated transgenic parasites overexpressing LdRab5a, LdRab5b, or their dominant-positive...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27226564
DOI: 10.1074/jbc.M116.716514
PMCID: PMC4938191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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