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Article

Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.

Antioxidants & redox signaling - 20 Dec 2016

Gorelenkova Miller Olga, Behring Jessica Belle, Siedlak Sandra L, Jiang Sirui, Matsui Reiko, Bachschmid Markus M, Zhu Xiongwei, Mieyal John J

Abstract excerpt

AIMS: Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts, including diabetes. In this study, we investigated the potential impact of Grx1 upregulation in the...

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Identifiers

PMID: 27224303
DOI: 10.1089/ars.2015.6598
PMCID: PMC5175443

Genes

TNF
GLRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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