Article
Functional complementation of Leishmania (Leishmania) amazonensis AP endonuclease gene (lamap) in Escherichia coli mutant strains challenged with DNA damage agents.
Memorias do Instituto Oswaldo Cruz - 1 May 2016
Verissimo-Villela Erika, Kitahara-Oliveira Milene Yoko, Reis Ana Beatriz de Bragança Dos, Albano Rodolpho Mattos, Da-Cruz Alda Maria, Bello Alexandre Ribeiro
Abstract excerpt
During its life cycle Leishmania spp. face several stress conditions that can cause DNA damages. Base Excision Repair plays an important role in DNA maintenance and it is one of the most conserved mechanisms in all living organisms. DNA repair in trypanosomatids has been reported only for Old World Leishmania species. Here the AP endonuclease from Leishmania (L.) amazonensis was cloned, expressed in Escherichia...
Topics
- Amino Acid Sequence
- DNA Damage
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Escherichia coli
- Escherichia coli Proteins
- Leishmania braziliensis
- Molecular Sequence Data
- Mutation