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Article

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major.

Journal of molecular biology - 2 Nov 2007

Vidal Antonio E, Harkiolaki Maria, Gallego Claribel, Castillo-Acosta Victor M, Ruiz-Pérez Luis M, Wilson Keith, González-Pacanowska Dolores

Abstract excerpt

Apurinic/apyrimidinic endonucleases initiate the repair of abasic sites produced either spontaneously, from attack of bases by reactive oxygen species or as intermediates during base excision repair. The catalytic properties and crystal structure of Leishmania major apurinic/apyrimidinic endonuclease are described and compared with those of human APE1 and bacterial exonuclease III. The purified enzyme is shown to...

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Share to Crystallography, X-Ray
Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoretic Mobility Shift Assay

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Source

Identifiers

PMID: 17870086
DOI: 10.1016/j.jmb.2007.08.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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