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Article

Cellular ageing mechanisms in osteoarthritis

23 May 2016

Abstract excerpt

Age is the strongest independent risk factor for the development of osteoarthritis (OA) and for many years this was assumed to be due to repetitive microtrauma of the joint surface over time, the so-called 'wear and tear' arthritis. As our understanding of OA pathogenesis has become more refined, it has changed our appreciation of the role of ageing on disease. Cartilage breakdown in disease is not a passive...

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PMID: 27215642
DOI: 10.1007/s00335-016-9641-z

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