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Article

The impact of the MYB-NFIB fusion proto-oncogene in vivo.

Oncotarget - 31 May 2016

Mikse Oliver R, Tchaicha Jeremy H, Akbay Esra A, Chen Liang, Bronson Roderick T, Hammerman Peter S, Wong Kwok-Kin

Abstract excerpt

Recurrent fusion of the v-myb avian myelobastosis viral oncogene homolog (MYB) and nuclear factor I/B (NFIB) generates the MYB-NFIB transcription factor, which has been detected in a high percentage of individuals with adenoid cystic carcinoma (ACC). To understand the functional role of this fusion protein in carcinogenesis, we generated a conditional mutant transgenic mouse that expresses MYB-NFIB along with p53...

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Topics

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Share to Gene Fusion
Share to Genes, p53
Share to Glomerulonephritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperplasia

Share to Mammary Neoplasms, Experimental

Share to Oncogene Proteins, Fusion

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Share to Salivary Glands

Source

Open in PubMed Open full text

Identifiers

PMID: 27213588
DOI: 10.18632/oncotarget.9426
PMCID: PMC5077968

Genes

MYB
NFIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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