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Article

Development and Characterization of MYB-NFIB Fusion Expression in Adenoid Cystic Carcinoma

30 Apr 2022

Abstract excerpt

Adenoid cystic carcinoma (ACC) is the second most common cancer type arising from the salivary gland. The frequent occurrence of chromosome t(6;9) translocation leading to the fusion of MYB and NFIB transcription factor genes is considered a genetic hallmark of ACC. This inter-chromosomal rearrangement may encode multiple variants of functional MYB-NFIB fusion in ACC. However, the lack of an ACC model that...

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PMID: 35565392
DOI: 10.3390/cancers14092263

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