Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling

30 Jan 2017

Abstract excerpt

Background: Adenoid cystic carcinoma (ACC) is an aggressive cancer with no curative treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the main genomic hallmark and a potential therapeutic target. Methods: Oncogenic signaling pathways were studied in cultured cells and/or tumors from 15 ACC patients. Phospho-receptor tyrosine kinase (RTK) arrays were used to study the activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Salivary Gland Disorders and Functions
Share to Salivary Gland Tumors Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28954282
DOI: 10.1093/jnci/djx017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT SignalingPMID 28954282Read ↗

Development and Characterization of MYB-NFIB Fusion Expression in Adenoid Cystic CarcinomaSemantic proximity Read ↗

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profilingSemantic proximity Read ↗

ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinomaSemantic proximity Read ↗

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials.Semantic proximity Read ↗

Adenoid cystic carcinoma: emerging role of translocations and gene fusionsSemantic proximity Read ↗

A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targetsSemantic proximity Read ↗

IGF2/IGF1R Signaling as a Therapeutic Target in MYB-Positive Adenoid Cystic Carcinomas and Other Fusion Gene-Driven TumorsSemantic proximity Read ↗

Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance.Semantic proximity Read ↗

MYB-fusions and other potential actionable targets in adenoid cystic carcinoma.Semantic proximity Read ↗

The mutational landscape of adenoid cystic carcinoma.Semantic proximity Read ↗

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.Semantic proximity Read ↗

MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.