Article
Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients.
Breast cancer research : BCR - 1 Jan 2008
Lee Eunjung, McKean-Cowdin Roberta, Ma Huiyan, Chen Zhengjia, Van Den Berg David, Henderson Brian E, Bernstein Leslie, Ursin Giske
Abstract excerpt
INTRODUCTION: Efforts are ongoing to determine the significance of unclassified variants (UVs) in the breast cancer susceptibility genes BRCA1/BRCA2, but no study has systematically assessed whether women carrying the suspected deleterious UVs have characteristics commonly seen among women carrying known deleterious or disease-causing mutations in BRCA1/BRCA2. METHODS: We sequenced BRCA1/BRCA2 in 1,469...
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