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Article

BRCA1 and BRCA2 unclassified variants and missense polymorphisms in Algerian breast/ovarian cancer families.

Disease markers - 1 Jan 2012

Cherbal Farid, Salhi Nadjet, Bakour Rabah, Adane Saida, Boualga Kada, Maillet Philippe

Abstract excerpt

BACKGROUND: BRCA1 and BRCA2 germline mutations predispose heterozygous carriers to hereditary breast/ovarian cancer. However, unclassified variants (UVs) (variants with unknown clinical significance) and missense polymorphisms in BRCA1 and BRCA2 genes pose a problem in genetic counseling, as their impact on risk of breast and ovarian cancer is still unclear. The objective of our study was to identify UVs and...

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Source

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Identifiers

PMID: 22684231
DOI: 10.3233/DMA-2012-0893
PMCID: PMC3826381

Genes

BRCA1
BRCA2

Variants

Provenance

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