Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth

9 Jan 2017

Abstract excerpt

Melanoma is the most lethal form of skin cancer and treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors show only temporary benefit due the occurrence of resistance and immunotherapy is effective only in a subset of patients. To improve patient survival, there is a need to better understand molecular mechanisms that drive melanoma growth and operate downstream of the mitogen activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Chronic Myeloid Leukemia Treatments
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28068326
DOI: 10.1038/onc.2016.481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growthPMID 28068326Read ↗

AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma.Semantic proximity Read ↗

POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulationSemantic proximity Read ↗

ERBB4 Drives the Proliferation of BRAF-WT Melanoma Cell LinesSemantic proximity Read ↗

The role of BPTF in melanoma progression and in response to BRAF-targeted therapy.Semantic proximity Read ↗

Up‐regulated deubiquitinase USP 4 plays an oncogenic role in melanomaSemantic proximity Read ↗

Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated FibroblastsSemantic proximity Read ↗

The interplay of CDK4 and CDK6 in melanomaSemantic proximity Read ↗

The Role of Fibroblasts in Melanoma Development: From Tumor Microenvironment Remodeling to Pre-Metastatic Niche FormationSemantic proximity Read ↗

Krüppel-like factors in tumors: Key regulators and therapeutic avenuesSemantic proximity Read ↗

Expression Pattern and Clinical Significance of E2F Transcription Factors in Skin Cutaneous MelanomaSemantic proximity Read ↗

TRAF6 Activates Fibroblasts to Cancer-Associated Fibroblasts through FGF19 in Tumor Microenvironment to Benefit the Malignant Phenotype of Melanoma Cells.Semantic proximity Read ↗

Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.