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Article

Curcumin improves LPS-induced preeclampsia-like phenotype in rat by inhibiting the TLR4 signaling pathway.

Placenta - 1 May 2016

Gong Ping, Liu Mo, Hong Guomin, Li Yujing, Xue Pingping, Zheng Mingming, Wu Mengfei, Shen Li, Yang Muyi, Diao Zhenyu, Hu Yali

Abstract excerpt

INTRODUCTION: Abnormal inflammation mediated by Toll-like receptor 4 (TLR4) signaling pathway contributes to preeclampsia (PE). Because curcumin can inhibit TLR4 signaling pathway, we investigated its effects on a PE rat model. METHODS: Twenty-one pregnant rats were randomly divided into three groups: 1) seven rats were injected 0.5 μg/kg lipopolysaccharide (LPS) on gestational day (GD) 5 to create a PE model...

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Source

Identifiers

PMID: 27208407
DOI: 10.1016/j.placenta.2016.03.002

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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