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Article

Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway.

Placenta - 1 Apr 2022

Zhang Jinwen, Jing Shiwen, Zhang Huijuan, Zhang Jun, Xie Hehui, Feng Liping

Abstract excerpt

INTRODUCTION: Clinical studies suggest that early pregnancy is the critical window for the prevention of preeclampsia by low-dose aspirin (LDA). Abnormal extravillous trophoblast (EVT) cell invasion and spiral artery remodeling during early placentation have been observed in preeclampsia cases. Thus, we hypothesized LDA prevents preeclampsia by mitigating EVT migration/invasion and spiral artery remodeling...

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Source

Identifiers

PMID: 35279428
DOI: 10.1016/j.placenta.2022.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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