Protective effect of annexin A5 against preeclampsia-like phenotypes in mice through the NF-κB/NLRP3 inflammasome pathway.

doi:10.1097/HJH.0000000000004246

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Article

Protective effect of annexin A5 against preeclampsia-like phenotypes in mice through the NF-κB/NLRP3 inflammasome pathway.

Journal of hypertension - 1 Oct 2026

Liu Xiaojing, Zhang Ziyi, Jin Ming, Ye Rongwei, Li Nan

Abstract excerpt

BACKGROUND AND OBJECTIVES: Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality, yet effective targeted therapies remain limited. This study aimed to investigate the therapeutic potential of annexin A5 (ANX A5) in PE and to elucidate the underlying mechanisms based on metabolomic profiling. METHODS: A PE-like mouse model was established by intraperitoneal injection of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41645566
DOI: 10.1097/HJH.0000000000004246

Genes

NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.