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Article

Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2016

Birch Camille L, Behunin Samantha M, Lopez-Pier Marissa A, Danilo Christiane, Lipovka Yulia, Saripalli Chandra, Granzier Henk, Konhilas John P

Abstract excerpt

Familial hypertrophic cardiomyopathy (HCM) is a disease of the sarcomere and may lead to hypertrophic, dilated, restrictive, and/or arrhythmogenic cardiomyopathy, congestive heart failure, or sudden cardiac death. We hypothesized that hearts from transgenic HCM mice harboring a mutant myosin heavy chain increase the energetic cost of contraction in a sex-specific manner. To do this, we assessed Ca(2+) sensitivity...

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Share to Calcium Signaling
Share to Cardiomyopathy, Hypertrophic, Familial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27199124
DOI: 10.1152/ajpheart.00592.2015
PMCID: PMC4967209

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