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Article

Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.

Pflugers Archiv : European journal of physiology - 1 Jun 2015

Najafi Aref, Schlossarek Saskia, van Deel Elza D, van den Heuvel Nikki, Güçlü Ahmet, Goebel Max, Kuster Diederik W D, Carrier Lucie, van der Velden Jolanda

Abstract excerpt

Hypertrophic cardiomyopathy (HCM), the most common genetic cardiac disorder, is frequently caused by mutations in MYBPC3, encoding cardiac myosin-binding protein C (cMyBP-C). Moreover, HCM is the leading cause of sudden cardiac death (SCD) in young athletes. Interestingly, SCD is more likely to occur in male than in female athletes. However, the pathophysiological mechanisms leading to sex-specific differences...

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Source

Identifiers

PMID: 25010737
DOI: 10.1007/s00424-014-1570-7

Genes

MYBPC3
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.PMID 25010737Read ↗

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