Article
Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.
Pflugers Archiv : European journal of physiology - 1 Jun 2015
Najafi Aref, Schlossarek Saskia, van Deel Elza D, van den Heuvel Nikki, Güçlü Ahmet, Goebel Max, Kuster Diederik W D, Carrier Lucie, van der Velden Jolanda
Abstract excerpt
Hypertrophic cardiomyopathy (HCM), the most common genetic cardiac disorder, is frequently caused by mutations in MYBPC3, encoding cardiac myosin-binding protein C (cMyBP-C). Moreover, HCM is the leading cause of sudden cardiac death (SCD) in young athletes. Interestingly, SCD is more likely to o...
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