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Article

Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining.

Cell reports - 27 Dec 2012

De Ioannes Pablo, Malu Shruti, Cortes Patricia, Aggarwal Aneel K

Abstract excerpt

DNA ligase IV (LigIV) and Artemis are central components of the nonhomologous end-joining (NHEJ) machinery that is required for V(D)J recombination and the maintenance of genomic integrity in mammalian cells. We report here crystal structures of the LigIV DNA binding domain (DBD) in both its apo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23219551
DOI: 10.1016/j.celrep.2012.11.004
PMCID: PMC3538150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23219551-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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