Article
World Health Organization grade II-III astrocytomas consist of genetically distinct tumor lineages.
Cancer science - 1 Aug 2016
Hattori Natsuki, Hirose Yuichi, Sasaki Hikaru, Nakae Shunsuke, Hayashi Saeko, Ohba Shigeo, Adachi Kazuhide, Hayashi Takuro, Nishiyama Yuya, Hasegawa Mitsuhiro, Abe Masato
Abstract excerpt
Recent investigations revealed genetic analysis provides important information in management of gliomas, and we previously reported grade II-III gliomas could be classified into clinically relevant subgroups based on the DNA copy number aberrations (CNAs). To develop more precise genetic subgrouping, we investigated the correlation between CNAs and mutational status of the gene encoding isocitrate dehydrogenase...
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