Article
PCR-Based Simple Subgrouping Is Validated for Classification of Gliomas and Defines Negative Prognostic Copy Number Aberrations in IDH Mutant Gliomas.
PloS one - 1 Jan 2015
Nakae Shunsuke, Sasaki Hikaru, Hayashi Saeko, Hattori Natsuki, Kumon Masanobu, Nishiyama Yuya, Adachi Kazuhide, Nagahisa Shinya, Hayashi Takuro, Inamasu Joji, Abe Masato, Hasegawa Mitsuhiro, Hirose Yuichi
Abstract excerpt
Genetic subgrouping of gliomas has been emphasized recently, particularly after the finding of isocitrate dehydrogenase 1 (IDH1) mutations. In a previous study, we investigated whole-chromosome copy number aberrations (CNAs) of gliomas and have described genetic subgrouping based on CNAs and IDH1 mutations. Subsequently, we classified gliomas using simple polymerase chain reaction (PCR)-based methods to improve...
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