Article
Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas.
The oncologist - 1 Sept 2016
Labussière Marianne, Rahimian Amithys, Giry Marine, Boisselier Blandine, Schmitt Yohann, Polivka Marc, Mokhtari Karima, Delattre Jean-Yves, Idbaih Ahmed, Labreche Karim, Alentorn Agusti, Sanson Marc
Abstract excerpt
BACKGROUND: The 1p19q non-codeleted gliomas with IDH mutation, defined as "molecular astrocytomas," display frequent TP53 mutations and have an intermediate prognosis. We investigated the prognostic impact of copy number-neutral loss of heterozygosity (CNLOH) in 17p in this population. METHODS: We analyzed 793 gliomas (206 grade II, 377 grade III, and 210 grade IV) by single nucleotide polymorphism array and for...
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