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Article

Prognostic relevance of mutations and copy number alterations assessed with targeted next generation sequencing in IDH mutant grade II glioma.

Journal of neuro-oncology - 1 Sept 2018

Wijnenga Maarten M J, French Pim J, Dubbink Hendrikus J, Dinjens Winand N M, Atmodimedjo Peggy N, Kros Johan M, Fleischeuer Ruth, Dirven Clemens M F, Vincent Arnaud J P E, van den Bent Martin J

Abstract excerpt

BACKGROUND: At current prognostication of low grade glioma remains suboptimal and might be improved with additional markers. These may guide treatment decisions, in particular on early adjuvant therapy versus wait and see after surgery. METHODS: We used a targeted Next-Generation Sequencing panel to assess mutational and copy number status of selected genes and chromosomes in a consecutive series of adult grade...

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Identifiers

PMID: 29663171
DOI: 10.1007/s11060-018-2867-8
PMCID: PMC6096891

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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