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Article

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.

PloS one - 1 Jan 2016

Sano Osamu, Tsujita Maki, Shimizu Yuji, Kato Reiko, Kobayashi Aya, Kioka Noriyuki, Remaley Alan T, Michikawa Makoto, Ueda Kazumitsu, Matsuo Michinori

Abstract excerpt

ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has been reported. In this study, we examined the effects of ABCG1 and ABCG4 on amyloid precursor protein (APP) processing, the product of which, amyloid β (Aβ), is...

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Share to Amyloid beta-Peptides
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 1

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Share to Gene Silencing

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Share to Membrane Glycoproteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 27196068
DOI: 10.1371/journal.pone.0155400
PMCID: PMC4872999

Genes

ABCG4
ABCG1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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