Article
Epistasis and the Dynamics of Reversion in Molecular Evolution.
Genetics - 1 Jul 2016
McCandlish David M, Shah Premal, Plotkin Joshua B
Abstract excerpt
Recent studies of protein evolution contend that the longer an amino acid substitution is present at a site, the less likely it is to revert to the amino acid previously occupying that site. Here we study this phenomenon of decreasing reversion rates rigorously and in a much more general context. We show that, under weak mutation and for arbitrary fitness landscapes, reversion rates decrease with time for any...
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