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Article

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Burkard Mark E, Randall Catherine L, Larochelle Stéphane, Zhang Chao, Shokat Kevan M, Fisher Robert P, Jallepalli Prasad V

Abstract excerpt

Polo-like kinases (Plks) play crucial roles in mitosis and cell division. Whereas lower eukaryotes typically contain a single Plk, mammalian cells express several closely related but functionally distinct Plks. We describe here a chemical genetic system in which a single Plk family member, Plk1,...

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Source

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Identifiers

PMID: 17360533
DOI: 10.1073/pnas.0701140104
PMCID: PMC1838611

Genes

PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360533-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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