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Article

New variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion.

Cancer science - 1 Aug 2016

Shimomura Yoshimitsu, Mitsui Hideki, Yamashita Yukiko, Kamae Tsuyoshi, Kanai Akinori, Matsui Hirotaka, Ishibashi Tomohiko, Tanimura Akira, Shibayama Hirohiko, Oritani Kenji, Kuyama Jun, Kanakura Yuzuru

Abstract excerpt

We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing followed by RT-PCR and direct sequencing revealed two types of fusion transcripts between exon 1B...

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Identifiers

PMID: 27193600
DOI: 10.1111/cas.12970
PMCID: PMC4982591

Genes

RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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