Article

Deep learning-based image quantification of epithelial cell shapes and its application to polycystic kidney disease

2025-08-16

Abstract excerpt

Cell shape is a fundamental determinant of tissue architecture and organ function. In epithelial tissues, cytoskeletal organization and tight junctions regulate cell geometry, shaping functional tissue units. Disruption of these mechanisms may cause diseases such as autosomal dominant polycystic kidney disease (ADPKD), in which cyst formation is characterized by abnormal regulation of epithelial cell shape. The me...

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Literature Corpus work: ea108c8a-aca0-5623-84f0-63927bfd08c7
DOI: 10.1101/2025.08.13.670046

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