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Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine

15 Apr 2016

Abstract excerpt

Because the benefits of immune checkpoint blockade may be restricted to tumors with pre-existing immune recognition, novel therapies that facilitate de novo immune activation are needed. DRibbles is a novel multi-valent vaccine that is created by disrupting degradation of intracellular proteins by the ubiquitin proteasome system. The DRibbles vaccine is comprised of autophagosome vesicles that are enriched with...

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PMID: 27190627
DOI: 10.1186/s40425-016-0130-4

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