Article
Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea.
mBio - 17 May 2016
Fu Xian, Liu Rui, Sanchez Iona, Silva-Sanchez Cecilia, Hepowit Nathaniel L, Cao Shiyun, Chen Sixue, Maupin-Furlow Julie
Abstract excerpt
UNLABELLED: The molecular mechanisms of targeted proteolysis in archaea are poorly understood, yet they may have deep evolutionary roots shared with the ubiquitin-proteasome system of eukaryotic cells. Here, we demonstrate in archaea that TBP2, a TATA-binding protein (TBP) modified by ubiquitin-like isopeptide bonds, is phosphorylated and targeted for degradation by proteasomes. Rapid turnover of TBP2 required...
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